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DNA and Cell Biology is the trusted source for authoritative, peer-reviewed reporting on the latest research in the field of molecular biology. Image/Mary Ann Liebert, Inc., publishers

Dengue: Do mast cells contribute to more severe disease?

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Why mosquito-borne dengue virus causes more severe disease in some individuals, including hemorrhagic fever with or without shock, remains controversial and researchers are focusing on the factors related...

Hookworm/CDC

Hookworm vaccine: George Washington University receive $3 million NIH grant

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Researchers at the George Washington University (GW) received a $3 million U01 grant from the National Institutes of Health to test the efficacy of a candidate recombinant hookworm vaccine, the next step...

Flu shot/CDC

Flu shot skepticism: Ontario residents question its importance and effectiveness, according to study

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Half of all people who avoid the flu shot do so because they question its importance and effectiveness, a new study from the University of Waterloo reports. The study reviewed Ontario health data from...

Schistosoma haemotobium egg Image/CDC

Cornell researchers develop process that may lead to vaccine for schistosomiasis

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Cornell and Ludwig Institute for Cancer Research scientists have developed a way to produce a protein antigen that may be useful as vaccine for schistosomiasis – a parasitic disease that infects millions...

Image/HIV-CDC

HIV investigational vaccine protected monkeys from HIV-like virus: Duke research

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Building on insights from an HIV vaccine regimen in humans that had partial success during a phase 3 clinical trial in Thailand, a Duke-led research team used a more-is-better approach in monkeys that...

HPV/NIH

HPV vaccines, testing and the prevention of cervical cancer

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A new review looks at cervical cancer screening in the era of HPV vaccination. The review notes that trials have demonstrated the efficacy and safety of vaccines against HPV infection, but the complete...

Results of a definitive clinical trial show that a new, disposable diagnostic patch effectively detects obstructive sleep apnea across all severity levels. Image/Somnarus, Inc.

Sleep apnea patch found effective in clinical trials

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Results of a definitive clinical trial show that a new, disposable diagnostic patch effectively detects obstructive sleep apnea across all severity levels. Results show that the total rate of clinical...

UTI test, EQUC, detects more bacteria than standard culture

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One of the primary ways physicians diagnose urinary tract infections is with a test that detects bacteria in urine. A new enhanced test, developed at Loyola University Chicago, detects significantly more...

Image/ C. S. Goldsmith, P. Rollin, M. Bowen This transmission electron micrograph (TEM) depicted numbers of Lassa virus virions adjacent to some cell debris. The virus, a member of the virus family Arenaviridae, is a single-stranded RNA virus, and is zoonotic, or animal-borne that can be transmitted to humans. The illness, which occurs in West Africa, was discovered in 1969 when two missionary nurses died in Nigeria, West Africa.In areas of Africa where the disease is endemic (that is, constantly present), Lassa fever is a significant cause of morbidity and mortality. While Lassa fever is mild or has no observable symptoms in about 80% of people infected with the virus, the remaining 20% have a severe multisystem disease. Lassa fever is also associated with occasional epidemics, during which the case-fatality rate can reach 50%. There are a number of ways in which the virus may be transmitted, or spread, to humans. The Mastomys rodents shed the virus in urine and droppings. Therefore, the virus can be transmitted through direct contact with these materials, through touching objects or eating food contaminated with these materials, or through cuts or sores. Because Mastomys rodents often live in and around homes and scavenge on human food remains or poorly stored food, transmission of this sort is common. Contact with the virus also may occur when a person inhales tiny particles in the air contaminated with rodent excretions. This is called aerosol or airborne transmission. Finally, because Mastomys rodents are sometimes consumed as a food source, infection may occur via direct contact when they are caught and prepared for food.

Details of Lassa virus structure could inform development of vaccines, therapies

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A 10-year Lassa virus research project has yielded structural and functional details of a key viral surface protein that could help advance development of Lassa vaccines and antibody-based therapeutics,...

Scientists at Yale University are working on a chemical process that may lead to the creation of a new class of antibiotics. Image/Michael S. Helfenbein

Antibiotics: New chemical process developed that may lead to new class

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Yale University scientists have developed a novel chemical process that may lead to the creation of a new class of antibiotics. The discovery comes at a time when more types of bacteria are becoming resistant...