Germany reports suspected Lassa fever death in Cologne | Outbreak News Today Outbreak News Today
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A individual who was referred to the University Hospital of Cologne for malaria treatment has died from suspected Lassa fever, according to German media (computer translated).

Image/ C. S. Goldsmith, P. Rollin, M. Bowen This transmission electron micrograph (TEM) depicted numbers of Lassa virus virions adjacent to some cell debris. The virus, a member of the virus family Arenaviridae, is a single-stranded RNA virus, and is zoonotic, or animal-borne that can be transmitted to humans. The illness, which occurs in West Africa, was discovered in 1969 when two missionary nurses died in Nigeria, West Africa.In areas of Africa where the disease is endemic (that is, constantly present), Lassa fever is a significant cause of morbidity and mortality. While Lassa fever is mild or has no observable symptoms in about 80% of people infected with the virus, the remaining 20% have a severe multisystem disease. Lassa fever is also associated with occasional epidemics, during which the case-fatality rate can reach 50%. There are a number of ways in which the virus may be transmitted, or spread, to humans. The Mastomys rodents shed the virus in urine and droppings. Therefore, the virus can be transmitted through direct contact with these materials, through touching objects or eating food contaminated with these materials, or through cuts or sores. Because Mastomys rodents often live in and around homes and scavenge on human food remains or poorly stored food, transmission of this sort is common. Contact with the virus also may occur when a person inhales tiny particles in the air contaminated with rodent excretions. This is called aerosol or airborne transmission. Finally, because Mastomys rodents are sometimes consumed as a food source, infection may occur via direct contact when they are caught and prepared for food.

C. S. Goldsmith, P. Rollin, M. Bowen

The patient was apparently in West Africa, admitted to the Cologne hospital for malaria, later died and on Wednesday the Bernhard Nocht Institute for Tropical Medicine’s postmortem examination revealed the suspected diagnosis of Lassa fever. “We then immediately inform the competent authorities, with whom we are now in close coordination” spokesman Timo Mügge said.

Lassa occurs in several countries in West Africa. In Germany, the disease occurs only rarely  and manifests when it is introduced by travelers from Africa. According to the Robert Koch Institute (RKI), since October 2011 – Germany for reported only five cases of the disease.

Both Nigeria and Benin are experiencing current Lassa fever outbreaks.

According to the US Centers for Disease Control and Prevention (CDC), Lassa fever is an acute viral illness that occurs in West Africa. The virus, a member of the virusfamily Arenaviridae, is a single-stranded RNA virus and is zoonotic, or animal-borne.

Lassa fever is a significant cause of morbidity and mortality. While Lassa fever is mild or has no observable symptoms in about 80% of people infected with the virus, the remaining 20% have a severe multisystem disease.

The animal host of Lassa virus is a rodent known as the “multimammate rat” of the genus Mastomys. Humans get infected with Lassa through aerosol or direct contact with excreta from the rodent. Laboratory infectionsdo occur primarily through contaminated needles.

The symptoms of Lassa fever typically occur 1-3 weeks after the patient comes into contact with the virus. These include fever, retrosternal pain (pain behind the chest wall), sore throat, back pain,



cough, abdominal pain, vomiting, diarrhea, conjunctivitis, facial swelling, proteinuria (protein in the urine), and mucosal bleeding. Neurological problems have also been described, including hearing loss, tremors, and encephalitis.

The Lassa virus and was 1st described in 1969 in the town of Lassa, in Borno State, Nigeria.



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