For decades, the routine treatment for Lyme disease has been standard antibiotics, which usually kill off the infection. But for up to 20% of people with the tick-borne illness, the antibiotics don’t work, and lingering symptoms of muscle pain, fatigue and cognitive impairment can continue for years — sometimes indefinitely.
A new Stanford Medicine study in lab dishes and mice provides evidence that the drug azlocillin completely kills off the disease-causing bacteria Borrelia burgdorferi at the onset of the illness. The study suggests it could also be effective for treating patients infected with drug-tolerant bacteria that may cause lingering symptoms.
“This compound is just amazing,” said Jayakumar Rajadas, PhD, assistant professor of medicine and director of the Biomaterials and Advanced Drug Delivery Laboratory at the Stanford School of Medicine. “It clears the infection without a lot of side effects. We are hoping to repurpose it as an oral treatment for Lyme disease.” Rajadas is the senior author of the study, which was published online March 2 in Scientific Reports. The lead author is research associate Venkata Raveendra Pothineni, PhD.
“We have been screening potential drugs for six years,” Pothineni said. “We’ve screened almost 8,000 chemical compounds. We have tested 50 molecules in the dish. The most effective and safest molecules were tested in animal models. Along the way, I’ve met many people suffering with this horrible, lingering disease. Our main goal is to find the best compound for treating patients and stop this disease.”
Read more at Stanford Medicine
I am very interested in any updates or trials for the compound discussed in this article and would love to know when in the future it may be released. I have chronic Lyme that went un-diagnosed which has turned into painful arthritis and serious problems with my feet that make it difficult to be on my feet for any length of time. I tested positive in 2018 for Lyme and was recently tested for Bartonella which came back negative. I was convinced, because of the severe hot flashes and foot problems, I had Bartonella, however, testing negative, I have no idea what is going on except I am miserable.
Shari Starr
I am German. I have Lyme disease since 20 years. Antibiotics helped ever only for a short time . At least I had extremely dangerous reactions from antibiotics. My heartbeat was much to high, my blood pressure was extremely high . But EKG was okay.
I had that luck that I read the study from dr Zhang for treatment Lyme with essential Oils. It helps great. I take Kakao butter and make it warm. If it becomes liquid, I put 20 drops oregano, cinnamon, lemmongras and for the blood pressure Majoran into this 50 ml liquid and I shake it. Then I put it with a Pipette into an enteric coated capsule and put it in the fridge. It helps to destroy Borreliose but you need bio essential oil. And second I take Andrographis Paniculata. Another name for andrographis is kalmegh. This kills spirochaete and is good for your stomach and for your heart. I mixes it with soda. If it is more red than green you can put it in tea or coffee and you will feel much better after hours. You can also take it as capsule.
Shari Starr – I also have Lyme and was having a severe hot flash every hour for months this past summer. Doctors thought it was hormonal, but I didn’t feel that it was. I started using BPC-157 and it got rid of them. When I ran out, they came back. My doctor said my hot flashes were caused by inflammation and the BPC-157 reduces inflammation. Hope this helps.
PLEASE CONTACT ME IF AND WHEN AZLOCILLIN IS AVAILABLE FOR HUMAN USE AND
AVAILABLE BY PRESCRIPTION IN ORAL OR INTRAVENOUS FORM. I AM HOPING THIS WILL
BE A CURE FOR CHRONIC LYME. PLEASE KEEP ME POSTED ON DEVELOPMENTS WITH AZLOCILLIN AND THERAPIES FOR CHRONIC LYME
Does anyone have the phone number or e mail of a Lyme Literate physician that is prescribing azlocillin and that works with chronic Lyme patients.
Please give us an update on this medication, I’ve literally lost all my 40’s to untold misery and now all my children have ii as well. We can’t wait, they are loosing all their youth, study, everything. Please when will this be ready for patients?