Sensitive New Assay Detects Hepatitis B Infection in Single Liver Cells and Serum


Hepatitis B virus (HBV) closed circular DNA (cccDNA) detection is of major clinical significance. HBV entry into the nucleus of liver cells (hepatocytes) stimulates cccDNA to create HBV RNAs that give rise to virus offspring. Measurement of cccDNA levels can help clinicians determine the level of HBV infection.
Image/Song-Mei Liu

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