On 17 March 2023, the Indonesia Ministry of Health notified WHO of the detection of a circulating vaccine-derived poliovirus type 2 (cVDPV2) in a 48-month-old female with acute flaccid paralysis (AFP), from Purwakarta district in West Java province, according to a World Health Organization Disease Outbreak News (DON).
The case had the onset of paralysis on 16 February 2023. The girl had not received any previous doses of oral poliovirus vaccine (OPV) or inactivated poliovirus vaccine (IPV).
A stool specimen was collected on 21 February 2023 and was confirmed to be cVDPV2 on 14 March 2023. Genetic sequencing results showed that the isolate has undergone 30 to 31 nucleotide changes from vaccine strains. The results of whole genome sequencing are pending.
The patient and her parents had no travel history within the month before the onset of AFP; however, during this period, the household had received visitors including relatives from another village.
A total of four confirmed cases of VDPV2 have been reported in Indonesia since November 2022. This includes three cases of circulating VDPV2 (cVDPV2) with acute flaccid paralysis (AFP) in Aceh province and one in West Java province. Additionally, four healthy children in Aceh province were confirmed to have cVDPV2 on 25 November 2022.