NewsDesk @bactiman63

Pennsylvania health officials published a very informative health advisory on Wednesday concerning Rabies Post Exposure Prophylaxis, which is definitely worth sharing.

Brown Bat
Myotis lucifugus, or Little Brown Bat/CDC

Below is the summary plus a link to the full advisory:

  • Rabies Post Exposure Prophylaxis (PEP) is indicated for patients with high-risk exposures such as bites and scratches from wild or potentially rabid animals.
  • For non-previously immunized individuals, PEP includes a single dose of Human Rabies
    Immunoglobin (HRIG) and rabies vaccine series administered on the day of exposure, with
    subsequent doses given on days 3, 7 and 14 following exposure. Immunocompromised
    individuals should receive a fifth dose on day 28.


  • For previously immunized individuals, PEP treatment is two doses of rabies vaccine given on
    days 0 and 3. HRIG should not be administered to previously immunized individuals.
  • HRIG should be infiltrated in and around the wound. Excess HRIG should be given
    intramuscularly at a separate anatomical site from the rabies vaccine.
  • Rabies vaccine should be given intramuscularly (IM) and should NOT be administered
    in the gluteal area.
  • It is important to ensure that HRIG and rabies vaccine are given properly, as improper
    administration could result in their poor uptake.

Click here for the full advisory