In an update on the Ebola disease caused by Sudan ebolavirus (SUDV) in Uganda, as of October 26, a total of 115 confirmed and 21 probable cases, including 32 confirmed and 21 probable deaths (CFR among confirmed cases: 27.8%) have been reported. Overall, 15 cases with four deaths have been reported among healthcare workers.
The most affected district is Mubende, which has reported 54.7% (n=63) of all confirmed cases, and in particular Madudu sub-county with 21 confirmed cases reported (18.2% of all confirmed cases).
There have been worries the spread of infection in Uganda could be difficult to control because currently there is no vaccine for the Sudan strain.
The World Health Organization initiated international consultations with vaccine developers to identify vaccine candidates against the Sudan ebolavirus that could be tested in randomized clinical studies in Uganda. Three candidate vaccines under consideration: cAd3, cAdOX1, and rVSV SUDV GP. The clinical study protocols are under review by the ethical and regulatory committees in Uganda.
At each stage of the clinical study, WHO prioritization committee will be reviewing evidence collected on the effectiveness and safety of the vaccine candidates to inform response activities.
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