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The Japanese Ministry of Health, Labor and Welfare announced the first confirmed case of acute hepatitis of unknown origin that corresponds with the provisional case definition outlined by the World Health Organization (WHO).
A local government reported a case of suspected hepatitis to the national government on April 21. The individual had negative results for the adenovirus, and has not had a liver transplant. They tested negative for the coronavirus, and it is unknown whether they have prexisting medical conditions. The health ministry has not revealed the individual’s symptoms, gender, age, nor where they live.
It is believed to be the first such case reported in Asia.
As of 21 April 2022, at least 169 cases of acute hepatitis of unknown origin have been reported from 11 countries in the WHO European Region and one country in the WHO Region of the Americas. Cases have been reported in the United Kingdom of Great Britain and Northern Ireland (the United Kingdom) (114), Spain (13), Israel (12), the United States of America (9), Denmark (6), Ireland (<5), The Netherlands (4), Italy (4), Norway (2), France (2), Romania (1), and Belgium (1).
Cases are aged 1 month to 16 years old. Seventeen children (approximately 10%) have required liver transplantation; at least one death has been reported.
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